ORPHERA Watch

Rare Disease Intel,
Delivered Monthly.

Track FDA orphan designations, clinical trials, patents, and competitor moves across rare disease drug development — all in one monthly intelligence report with real-time alerts.

$300 / month
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What your monthly brief looks like.

ORPHERA Watch — Monthly Intelligence Brief

April 2026

New Orphan Designations

FDA granted 14 new orphan drug designations this month, including 3 in neuromuscular diseases.

+14 new
🔬

Clinical Trial Updates

Phase 2 readout for CLZ-2002 (CMT) expected Q3. New Phase 1 initiated for HGPS combination therapy.

8 updates
📄

Patent Filings

New use-patent filed for Sirolimus + mTOR modulator combination in progeroid syndromes.

IP alert
📊

Competitor Moves

Healx announces $47M Series C. Recursion partners with Bayer for rare genetic diseases.

5 moves
📰

Key Publications

Nature Medicine publishes gene therapy results for DMD. 12 new repurposing studies indexed.

12 papers
⚖️

Regulatory Changes

ORPHAN Cures Act implementation update. New FDA guidance on rare disease clinical endpoints.

Policy shift
Full report includes: 30+ page analysis, disease-specific deep dives, strategic recommendations, data tables
Included
Everything in your subscription.

Monthly Intelligence Report

30+ page comprehensive brief covering all rare disease drug development activity from the past month.

Real-Time Email Alerts

Instant notifications when FDA grants new orphan designations, key trials post results, or competitors make moves.

FDA Orphan Drug Tracker

Complete database of active orphan designations, approvals, and pending applications — updated weekly.

Clinical Trial Monitor

Rare disease trials tracked across all phases. New initiations, completions, terminations, and readouts.

Patent & IP Watch

New filings, grants, and expirations for rare disease use-patents. Freedom-to-operate signals.

Custom Disease Focus

Choose up to 3 disease areas for deep-dive tracking. Get tailored alerts and analysis for your pipeline.

Simple, continuous intelligence.
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Choose your plan and set up your disease focus areas. $300/month, cancel anytime.

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Get your first monthly brief within 7 days. Real-time alerts start immediately.

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Use intelligence to guide pipeline decisions, identify opportunities, and stay ahead of competitors.

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We'll prioritize these areas in your monthly report and set up targeted alerts.
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Monthly Intelligence Subscription $300/mo
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You'll be redirected to PayPal for subscription setup. Real-time alerts begin immediately upon subscription.

Common questions.
What's included in the monthly report?
A 30+ page intelligence brief covering new orphan designations, clinical trial updates, patent filings, competitor activity, key publications, and regulatory changes — all specific to rare disease drug development.
How do real-time alerts work?
We monitor FDA, ClinicalTrials.gov, patent databases, and news sources daily. When something matches your disease focus areas, you get an email alert within 24 hours — not at the end of the month.
Can I change my disease focus areas?
Yes, anytime. Email us and your next report will reflect the updated focus. Alert filters update within 24 hours.
Is this different from PubMed alerts or FDA RSS feeds?
Yes. Raw feeds give you data. ORPHERA Watch gives you analysis — what matters, why it matters, and what it means for your pipeline. We synthesize signals across databases that you'd otherwise have to check separately.
Can I cancel anytime?
Yes. No lock-in, no cancellation fees. You'll retain access to all reports delivered during your subscription.
Do you offer annual plans?
Annual subscriptions are available at $3,000/year (2 months free). Contact us for enterprise pricing for teams of 3+.